- Disorders of Pleura, Mediastinum, and Chest Wall
- Costochondritis
- Mediastinitis
- Pleural Effusion
- Pleuritis
- Pneumomediastinum
- Pneumothorax
- Empyema
- Acute Respiratory Distress Syndrome (ARDS)
- Obstructive/Restrictive Lung Disease
- Asthma/Reactive Airway Disease
- Bronchitis
- Bronchopulmonary Dysplasia
- Chronic Obstructive Pulmonary Disease (COPD)
- Cystic Fibrosis
- Environmental/Industrial Exposure
- Bronchiolitis
- Physical and Chemical Irritants/Insults
- Pneumoconiosis
- Toxic Effects of Gases, Fumes, Vapors
- Pulmonary Embolism
- Septic Emboli
- Venous Thromboembolism
- Massive and Submassive Embolism
- Fat Emboli
- Pulmonary Infections
- Lung Abscess
- Pneumonia
- Aspiration Pneumonia
- Comunity-Acquired Pneumonia (CAP)
- Healthcare-Associated Pneumonia (HAP)
- Pneuocystis
- Pulmonary Tuberculosis
- Respiratory Syncytial Virus (RSV)
- Pertussis
- Pulmonary Tumors
- Pulmonary Hypertension

Asthma Exacerbation
Rapid Review
- Background
- Diffuse airway inflammation characterized by bronchial hyperresponsiveness and reversible airflow obstruction.
- Acute exacerbations can be caused by viral infections, allergens, tobacco, or emotional factors
- Signs/Symptoms
- Dyspnea, cough, chest tightness. May present in respiratory failure.
- (+) expiratory wheezing, (+) tripod positioning
- Diagnosis
- Clinical diagnosis in emergency setting
- Formal diagnosis made with spirometry
- Treatment
- Nebulizers (albuterol/ipratropium), steroids, +/- magnesium, +/- epinephrine.
- May require NIPPV or intubation
- Disposition
- Admit patients who continue to be tachypnic or hypoxic despite treatment (floor, observation, or ICU depending on severity).
- Patients who respond well to treatment can be discharged after a brief observation to ensure stability.
Pearls
- Be aggressive early in the management of asthma. Consider the use of epinephrine, similar to how you would use it with anaphylaxis.
- Due to it bronchodilatory effects, ketamine is the induction agent of choice for intubating asthmatics.
Deep Dive

Pleural Effusion
Rapid Review
- Background
- Accumulation of excess fluid between the pleural space outside of the lungs.
- May be transudative (due to fluid shifts) or exudative (due to infection, malignancy, etc.)
- Signs/Symptoms
- Dyspnea, pain with inspiration
- (+) decreased breath sounds, (+) decreased tactile fremitus, (+) dullness to percussion
- Diagnosis
- CXR (shows blunting of costophrenic angle). Chest CT/US can also be used.
- Thoracentesis is the gold standard. Light criteria used to differentiate transudative vs exudative effusion.
- Treatment
- Thoracentesis or tube thoracostomy (depending on size and etiology)
- Diuresis helpful if due to CHF
- Disposition
- Discharge is appropriate if patient is stable and the source of the effusion is known and being treated. Should have close follow-up.
- Admit patients with unknown sources or empyema. ICU is required for hemodynamically unstable.
Pearls
- In general, bilateral effusions tend to be from a transudative process (ex. CHF, cirrhosis) Unilateral effusions tend to be from an exudative process (ex. Infection, cancer, pancreatitis, etc.).
- Ultrasound is a useful adjunct for both identifying pleural effusions and reducing the risk of complications during thoracentesis.

Pneumonia (Bacterial)
Rapid Review
- Background
- Acute inflammation of the lungs caused by bacterial infection (typically S. pneumonia)
- Signs/Symptoms
- Symptoms: Fever/chills, cough, dyspnea, rigors, pleuritic chest pain
- Signs: Rust-colored sputum, tachycardia, rales/rhonchi
- Diagnosis
- Clinical findings, (+/-) CXR
- Treatment
- Antibiotics
- Outpatient (doxycycline or azithromycin)
- Inpatient (Ceftriaxone + azithromycin or fluoroquinolone)
- Antibiotics
- Disposition
- Patients < 65 years old who appear well and have access to PCP follow-up within 72 hours can be safely discharged.
- Admit anybody who doesnโt fit the above criteria. ICU if hemodynamically unstable.
Pearls
- The CURB-65 and the Pneumonia Severity Index are both available clinical scoring systems that can aid with disposition decisions.
- Always consider pneumonia in patients presenting with suspected exacerbation of underlying diseases (ex. Asthma, COPD, CHF)
Deep Dive

Pneumothorax
Rapid Review
- Background
- Accumulation of free air in the pleural space, causing partial or complete collapse of the lung.
- Can be spontaneous (blebs, COPD, TB), iatrogenic (central line, thoracentesis), or traumatic (blunt/penetrating trauma)
- Signs/Symptoms
- Symptoms: dyspnea, ipsilateral chest pain
- Signs: (+) hyperresonance, (+) diminished breath sounds, (+) decreased tactile fremitus
- Diagnosis
- CXR (absent lung markings along periphery)
- Treatment
- Small pneumothorax (<15%) can be observed
- Large pneumothorax (>15%) require thoracostomy
- Disposition
- Patients with resolution from spontaneous pneumothorax following treatment may be discharged with follow-up in 24-48 hours
- Admit patients with tension pneumothorax or those requiring a chest tube.
Pearls
- Stardard IV angiocatheters are too short to adequately penetrate the pleural cavity, especially in larger framed individuals. Use pneumothorax specific catheters when possible.
- JVD, hypotension, and tracheal deviation are late signs of tension pneumothorax. Do not wait for these signs to initiate treatment.
Deep Dive

Pulmonary Embolism
Rapid Review
- Background
- Occlusion of pulmonary arteries by thrombi that typically originate from the lower extremities or pelvis
- Signs/Symptoms
- Symptoms: Dyspnea (most common), pleuritic chest pain, syncope
- Signs: (+) tachypnea, (+) tachycardia, (+) hypotension
- Diagnosis
- CT PE is the gold standard
- CXR may show โwestermark signโ or โHampton humpโ
- Treatment
- O2, anticoagulation (heparin, LMWH), hemodynamic support (fluids, pressors)
- Thrombolytics for unstable patients.
- Disposition
- Most patients with PE will be admitted. ICU if high risk for hemodynamic collapse.
- Patients who are low risk and do not have right heart strain may be considered for discharge on anticoagulation and close follow-up.
Pearls
- EKG findings (ex. tachycardia, new T wave inversions, rightward axis) cannot definitively rule in/rule out pulmonary embolism, but may help push you to search for it.
- A V/Q study is a reasonable alternative for pregnant patients, but tends to take longer and is less valuable in determining alternative etiologies.
Deep Dive
